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By B.E. Strauer

within the Federal Republic of Germany this day there are 6 to eight million hypertensive sufferers. Of them, three to four million express natural cardiac manifestations of high blood pressure. Of all deaths taking place prior to the age of sixty five, forty% are brought on by high blood pressure, and the full mortality from high blood pressure is set 25%. The excessive cardiac morbidity and mortality strength of the danger issue 'hyper­ stress' lies within the improvement of cardiac hypertrophy, center failure and coronary artery illness. moreover, hypertensive sufferers are predisposed to increase secondary cardiac ailments. the purpose of the current examine was once to examine the myocardial functionality and coronary haemodynamics in crucial high blood pressure, i. e. the most typical kind of strain load imposed at the human center. accordingly, the functionality and mode of operation of the hypertensive center are defined - a kind of hypertrophy of the human center which thus far has nearly been missed in pathophysiology and diagnostics. at the foundation of the findings, conclusions are drawn for the differential analysis and remedy of the hypertensive center followed via hypertrophy, center failure and coronary artery disorder. This paintings used to be supported through Deutsche Forschungsgemeinschaft. The help in translating this manuscript through Petra Froschen, Christine Ebel and Cornelia Leisse is gratefully acknowledged.

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